Serodiagnosis of Scrub Typhus by Dot-Blot Method

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Performance of a dot blot immunoassay for the rapid diagnosis of scrub typhus in a longitudinal case series.

A rapid dipstick test for scrub typhus was prospectively evaluated in Chiangrai, northern Thailand. Sera from 162 patients with fever of unclear etiology were tested by a dot blot immunoassay using two different antigen concentrations. Dipsticks coated with lower concentration of antigen lacked sensitivity compared with the indirect immunoperoxidase test. Dipsticks with higher antigen concentra...

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Scrub typhus is an important emerging tropical infection that can have severe manifestations in children leading to intensive care admission. It is caused by Orientia tsutsugamushi, a gram negative bacterium transmitted to humans by the bite of larval trombiculid mites. The organism is endemic in south-east Asia and the disease is reported from virtually all parts of India. The hallmark of this...

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Thailand is a developing country that is still grappling with infectious diseases. Although modern medical and laboratory technology have been applied in the investigation and treatment of in­ fectious diseases, they are still prevalent. The varied ecology and topography of Thailand are appro­ priate for infective organisms, but there is a lack of medical apparatus and health personnel for cont...

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ژورنال

عنوان ژورنال: Journal of the Japanese Association for Infectious Diseases

سال: 1990

ISSN: 1884-569X,0387-5911

DOI: 10.11150/kansenshogakuzasshi1970.64.704